*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE5300000
CHEMICAL NAME           : Ergoline-8-beta-carboxamide,
                          9,10-didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimeth
                          yl-
CAS REGISTRY NUMBER     : 361-37-5
BEILSTEIN REFERENCE NO. : 0765985
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H27-N3-O2
MOLECULAR WEIGHT        : 353.51
WISWESSER LINE NOTATION : T C6656 1A P GN LN CUTT&&J EVMY2&1Q G1 L1
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Deseril
   * Desernyl
   * Deseryl
   * Methyllysergic acid butanolamide
   * 1-Methyllysergic acid butanolamide
   * Methysergid
   * Methysergide
   * UML 491
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 28 ug/kg
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Behavioral - headache
   Gastrointestinal - nausea or vomiting
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 16,220,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963
 
                            *** END OF RECORD ***