*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KE6168000 CHEMICAL NAME : Ergoline-8-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)- 6-(2-propenyl)- (8-beta)-, phosphate (1:2) CAS REGISTRY NUMBER : 85329-89-1 LAST UPDATED : 199509 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C26-H37-N5-O2.2H3-O4-P MOLECULAR WEIGHT : 647.68 COMPOUND DESCRIPTOR : Drug Reproductive Effector Human SYNONYMS/TRADE NAMES : * Centralvet * FCE 21336 * Vetem *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 15 ug/kg SEX/DURATION : lactating female 1 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - postpartum Endocrine - effect on menstrual cycle REFERENCE : JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 36,717,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE : 25 ug/kg SEX/DURATION : female 6-7 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 29,1233,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE : 5 ug/kg SEX/DURATION : female 6-7 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 29,1233,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE : 8250 ng/kg SEX/DURATION : female 30-34 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion REFERENCE : AMVRA4 Annales de Medecine Veterinaire. (Annales de Medecine Veterinaire, Rue des Veterinaires, 45, B-1070 Brussels, Belgium) V.1- 1852- Volume(issue)/page/year: 137,251,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE : 8250 ng/kg SEX/DURATION : female 30-34 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion REFERENCE : JRFSAR Journal of Reproduction and Fertility, Supplement. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) No.1- 1966- Volume(issue)/page/year: 47,411,1993 *** END OF RECORD ***