*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE6168000
CHEMICAL NAME           : Ergoline-8-carboxamide,
                          N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-
                          6-(2-propenyl)- (8-beta)-, phosphate (1:2)
CAS REGISTRY NUMBER     : 85329-89-1
LAST UPDATED            : 199509
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C26-H37-N5-O2.2H3-O4-P
MOLECULAR WEIGHT        : 647.68
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Centralvet
   * FCE 21336
   * Vetem
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 15 ug/kg
SEX/DURATION            : lactating female 1 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
   Endocrine - effect on menstrual cycle
REFERENCE :
   JRPMAP Journal of Reproductive Medicine.  (2 Jacklynn Ct., St. Louis, MO
   63132)  V.3-    1969-  Volume(issue)/page/year: 36,717,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 25 ug/kg
SEX/DURATION            : female 6-7 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 29,1233,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 5 ug/kg
SEX/DURATION            : female 6-7 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 29,1233,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 8250 ng/kg
SEX/DURATION            : female 30-34 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   AMVRA4 Annales de Medecine Veterinaire.  (Annales de Medecine Veterinaire,
   Rue des Veterinaires, 45, B-1070 Brussels, Belgium)  V.1-    1852-
   Volume(issue)/page/year: 137,251,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE                    : 8250 ng/kg
SEX/DURATION            : female 30-34 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   JRFSAR Journal of Reproduction and Fertility, Supplement.  (Biochemical Soc.
   Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) No.1-   
   1966-  Volume(issue)/page/year: 47,411,1993
 
                            *** END OF RECORD ***