*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KD1675000
CHEMICAL NAME           : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)
                          furan-1,11(2H)-dione, 8-(N-(4-benzyl-2,
                          6-dimethyl-1-piperazinyl)formimidoyl)-5,6,9,17,19,21-
                          hexahydroxy-23-methox y-2,4,12,16,18,20,
                          22-heptamethyl-, 21-acetate
CAS REGISTRY NUMBER     : 13292-47-2
LAST UPDATED            : 198610
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C51-H66-N4-O12
MOLECULAR WEIGHT        : 927.21
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * AF/Abdp
   * AF Flash ABDP
   * Dimethylbenzyldemethylrifampicin
   * 2,6-Dimethyl-4-benzyl-4-demethyl-rifampicin
   * Dimethylbenzyldesmethylrifampicin
   * Rifampicin AF/abdp
   * Rifamycin,  
   3-(((2,6-dimethyl-4-(phenylmethyl)-1-piperazinyl)imino)methyl)- 9(CI)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38KLAC "Structure-Activity Relationship among the Semisynthetic
   Antibiotics,"  Perlman, D., ed., New York, Academic Press, 1977
   Volume(issue)/page/year: -,531,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 60,96,1974
 
                            *** END OF RECORD ***