*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE6345160
CHEMICAL NAME           : Ergoline-8-propionamide,
                          9,10-didehydro-alpha-cyano-6-methyl-, (8-beta)-
CAS REGISTRY NUMBER     : 88133-19-1
LAST UPDATED            : 199609
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H20-N4-O
MOLECULAR WEIGHT        : 320.43
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   *   2-Cyano-3-(5(10-9)abeo-9,10-didehydro-6-methyl-ergoline-8-beta)propionam
     ide
   * alpha-Cyano-6-methyl-9,10-didehydroergoline-8-propionamide
   * 9,10-Didehydro-alpha-cyano-6-methylergoline-8-propionamide
   * 9,10-Didehydro-alpha-cyano-6-methylergoline-8-beta-propionamide
   * Ergoline-8-propanamide, alpha-cyano-9,10-didehydro-6-methyl-, (8-beta)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #16411
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16 mg/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,1094,1983
 
                            *** END OF RECORD ***