*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE7648500
CHEMICAL NAME           : Ergotaman-3',6',18-trione,
                          12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,
                          (5'-alpha)-, (R-(R*,R*))-2,3-dihydroxybutanedioate
                          (2:1) (salt), mixt. with 3,7-dihydro-1,3,7-trimethyl-
                          1H-purine-2,6-dione
CAS REGISTRY NUMBER     : 69063-86-1
LAST UPDATED            : 199412
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C66-H70-N10-O10.C16-H20-N8-O4.C4-H6-O6
MOLECULAR WEIGHT        : 1702.00
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Cafergamine
   * Cafergot
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 5120 ug/kg/32D-I
TOXIC EFFECTS :
   Vascular - regional or general arteriolar constriction
REFERENCE :
   HUTODJ Human Toxicology.  (Macmillan Press Ltd., Houndmills, Basingstoke,
   Hants., RG 21 2XS, UK) V.1-    1981-  Volume(issue)/page/year: 5,61,1986
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 3464 mg/kg
SEX/DURATION            : female 1-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
REFERENCE :
   CPEDAM Clinical Pediatrics (Philadelphia).  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1962-
   Volume(issue)/page/year: 22,226,1983
 
                            *** END OF RECORD ***