*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE7920000
CHEMICAL NAME           : Ergotamine, 9,10-dihydro-, monomethanesulfonate
                          (salt)
CAS REGISTRY NUMBER     : 6190-39-2
LAST UPDATED            : 199509
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C33-H37-N5-O5.C-H4-O3-S
MOLECULAR WEIGHT        : 679.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * DETMS
   * DHE 45
   * Dihydergot
   * Dihydroergotamine mesilate
   * Dihydroergotamine mesylate
   * 9,10-Dihydroergotamine mesylate
   * Dihydroergotamine methanesulfonate
   * Dihytamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,468,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,468,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,328,1982
 
                            *** END OF RECORD ***