*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KE8000000
CHEMICAL NAME           : Ergotamine, dihydro-, tartrate (2:1)(salt)
CAS REGISTRY NUMBER     : 5989-77-5
LAST UPDATED            : 199712
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C66-H74-N10-O10.C4-H6-O6
MOLECULAR WEIGHT        : 1317.60
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dihydroergotamine tartrate (2:1)
   * 9,10-Dihydroergotamine tartrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSAMA5 Bulletin der Schweizerischen Akademie der Medizinischen
   Wissenschaften. (Schwabe & Co., Steinentorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 2,1,1946/1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,284,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSAMA5 Bulletin der Schweizerischen Akademie der Medizinischen
   Wissenschaften. (Schwabe & Co., Steinentorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 2,1,1946/1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSAMA5 Bulletin der Schweizerischen Akademie der Medizinischen
   Wissenschaften. (Schwabe & Co., Steinentorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 2,1,1946/1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSAMA5 Bulletin der Schweizerischen Akademie der Medizinischen
   Wissenschaften. (Schwabe & Co., Steinentorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 2,1,1946/1947
 
                            *** END OF RECORD ***