*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KF2305000
CHEMICAL NAME           : Erythritol,
                          1,4-dideoxy-1,4-bis((2-hydroxyethyl)amino)-,
                          1,4-dimethanesulfonate (ester), meso-
CAS REGISTRY NUMBER     : 4148-16-7
LAST UPDATED            : 199410
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H24-N2-O8-S2
MOLECULAR WEIGHT        : 364.48
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1,4-Bis(2'-mesyloxyethylamino)-1,4-dideoxymesoerythritol
   * 1,4-Dideoxy-1,4-bis((2-hydroxyethyl)amino)erythritol  
   1,4-dimethanesulfonate (ester)
   * 1,4-Di(mesyloxyethylamino)erythritol
   * 3,14-Dioxa-2,15-dithia-6,11-diazahexadecane-8,9-diol,  
   2,2,15,15-tetraoxide, (R*,S*)-
   * Lycurim
   * Lykurim
   * 1,4-(Methylsulfonyloxyethylamino)-1,4-dideoxy-erythrioldimethylsulfonate
   * NSC-122402
   * R 74 base
   * Ritrosulfan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 54210 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 mg/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,4530,1983
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 1300 ng/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,4530,1983
 
                            *** END OF RECORD ***