*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KF5775000
CHEMICAL NAME           : Erythromycin, propionate (ester), compd. with
                          monododecyl sulfate (1:1)
CAS REGISTRY NUMBER     : 3521-62-8
LAST UPDATED            : 199504
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C40-H71-N-O14.C12-H26-O4-S
MOLECULAR WEIGHT        : 1056.56
WISWESSER LINE NOTATION : T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ
                          CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Eritroger
   * Eromycin
   * Erythromycin estolate
   * Erythromycin propionate, compd. with dodecyl sulfate
   * Erythromycin 5-(3-propionate) dodecyl sulfate
   * Erythromycin propionate lauryl sulfate
   * Erythromycin propionyl laurylsulfate
   * Ilosone
   * Lauromicina
   * Lauryl sulfate propionyl erythromycin ester
   * Neo-erycinum
   * Roxomicina
   * Stellamicina
   * Sulfuric acid, monododecyl ester, compd. with erythromycin propionate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1447 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,211,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,211,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,211,1990
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48488 mg/kg/6W-I
TOXIC EFFECTS :
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   25,435,1967

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5545
       No. of Facilities: 39 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 1088 (estimated)
       No. of Female Employees: 542 (estimated)

 
                            *** END OF RECORD ***