*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG3750000
CHEMICAL NAME           : 17-alpha-Estradiol
CAS REGISTRY NUMBER     : 57-91-0
BEILSTEIN REFERENCE NO. : 2698044
REFERENCE               : 4-06-00-06611 (Beilstein Handbook Reference)
LAST UPDATED            : 199803
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H24-O2
MOLECULAR WEIGHT        : 272.42
WISWESSER LINE NOTATION : L E5 B666TTT&J E1 FQ OQ  17-ALPHA
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Hormone
SYNONYMS/TRADE NAMES :
   * 3,17-Dihydroxyestratriene
   * 3,17-alpha-Dihydroxyoestra-1,3,5(10)-triene
   * Epiestradial
   * alpha-Estradiol
   * Estra-1,3,5(10)-triene-3,17-diol, (17-alpha)-
   * 1,3,5-Estratriene-3,17-alpha-diol
   * Oestradiol-17-alpha
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   RBBIAL Revista Brasileira de Biologia.  Brazilian Review of Biology.
   (Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro,
   Brazil)  V.1-    1941-  Volume(issue)/page/year: 5,1,1945
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 100 mg/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 10,143,1982
 
                            *** END OF RECORD ***