*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KG6125000
CHEMICAL NAME : Estra-1,3,5,7,9-pentaen-17-one, 3-hydroxy-
CAS REGISTRY NUMBER : 517-09-9
BEILSTEIN REFERENCE NO. : 2335367
REFERENCE : 4-08-00-01420 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C18-H18-O2
MOLECULAR WEIGHT : 266.36
WISWESSER LINE NOTATION : L E5 B666 FVTT&&J E1 OQ
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Equilenin
* (+)-Equilenin
* d-Equilenin
* Equilenina
* Equilenine
* Estra-1,3,5(10),6,8-pentaen-17-one, 3-hydroxy-
* 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1600 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
BSBSAS Boletin de la Sociedad de Biologia de Santiago de Chile. (Santiago,
Chile) V.1-12, 1943-55. Discontinued. Volume(issue)/page/year: 8,142,1951
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 640 mg/kg/38W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,5200,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 17 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
RBBIAL Revista Brasileira de Biologia. Brazilian Review of Biology.
(Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro,
Brazil) V.1- 1941- Volume(issue)/page/year: 5,1,1945
*** END OF RECORD ***