*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KG6650000 CHEMICAL NAME : Estra-1,3,5(10),7-tetraen-17-one, 3-hydroxy- CAS REGISTRY NUMBER : 474-86-2 BEILSTEIN REFERENCE NO. : 2624302 REFERENCE : 4-08-00-01366 (Beilstein Handbook Reference) LAST UPDATED : 199709 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H20-O2 MOLECULAR WEIGHT : 268.38 WISWESSER LINE NOTATION : L E5 B666 FV JUTTT&J E1 OQ COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * 7-Dehydroestrone * Equilin * 1,3,5,7-Estratetraen-3-ol-17-one * 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 112 mg/kg/56W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors REFERENCE : ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 56,482,1949 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 640 mg/kg/38W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,5200,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 168 mg/kg/42W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : YJBMAU Yale Journal of Biology and Medicine. (333 Cedar St., New Haven, CT 06510) V.1- 1928- Volume(issue)/page/year: 12,213,1939 ** MUTATION DATA ** TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - mouse DOSE/DURATION : 400 mg/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,14,1988 *** END OF RECORD ***