*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG6650000
CHEMICAL NAME           : Estra-1,3,5(10),7-tetraen-17-one, 3-hydroxy-
CAS REGISTRY NUMBER     : 474-86-2
BEILSTEIN REFERENCE NO. : 2624302
REFERENCE               : 4-08-00-01366 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H20-O2
MOLECULAR WEIGHT        : 268.38
WISWESSER LINE NOTATION : L E5 B666 FV JUTTT&J E1 OQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 7-Dehydroestrone
   * Equilin
   * 1,3,5,7-Estratetraen-3-ol-17-one
   * 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 mg/kg/56W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   56,482,1949
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 640 mg/kg/38W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,5200,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 168 mg/kg/42W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   YJBMAU Yale Journal of Biology and Medicine.  (333 Cedar St., New Haven, CT
   06510)  V.1-    1928-  Volume(issue)/page/year: 12,213,1939
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,14,1988
 
                            *** END OF RECORD ***