*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KG7300000
CHEMICAL NAME : Estra-1,3,5(10)-triene-3,17-beta-diol,
bis(p-(bis(2-chloroethylamino)phenyl)acetate)
CAS REGISTRY NUMBER : 22966-79-6
LAST UPDATED : 199701
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C42-H50-Cl4-N2-O4
MOLECULAR WEIGHT : 788.74
WISWESSER LINE NOTATION : L E5 B666TTT&J E1 FOV1R DN2G2G& OOV1R DN2G2G
COMPOUND DESCRIPTOR : Tumorigen
Drug
Hormone
SYNONYMS/TRADE NAMES :
* Bis((4-(bis(2-chloroethyl)amino)benzene)acetate)estra-1,3,5(10)-triene-3
,17-diol(17beta)
* Bis((4-(bis(2-chloroethyl)amino)benzene)acetate)oestra-1,3,5(10)-triene-
3,17-diol(17beta)
* Bis((p-(bis(2-chloroethyl)amino)phenyl)acetate)estradiol
* Bis((p-(bis(2-chloroethyl)amino)phenyl)acetate)estra-1,3,5(10)-triene-3,
17-beta-diol
* Bis((p-(bis(2-chloroethyl)amino)phenyl)acetate)oestradiol
* Bis((p-bis(2-chloroethyl)aminophenyl)acetate)oestra-1,3,5(10)-triene-3,1
7-beta-diol
* Estradiol mustard
* NCI-C01570
* NSC 112259
* Oestradiol mustard
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 560 mg/kg/14D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6,
1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
4,121,1973
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2340 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-59,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 480 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
33,3069,1973
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4680 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-59,1978
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,217,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,217,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-59,78
NCI Carcinogenesis Bioassay (gavage);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-59,78
*** END OF RECORD ***