*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG7400000
CHEMICAL NAME           : 17-beta-Estra 1,3,5(10)-triene-3,17-diol,
                          17-dihydrogen phosphate, homopolymer
CAS REGISTRY NUMBER     : 34828-67-6
LAST UPDATED            : 199509
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Polyestradiol phosphate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg/60D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - leukemia
   Musculoskeletal - tumors
REFERENCE :
   ATHBA3 Acta Radiologica: Therapy, Physics, Biology.  (Stockholm, Sweden)
   V.1-16, 1963-77.  Volume(issue)/page/year: 12,209,1973
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE                    : 41 mg/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ASUPAZ Acta Societatis Medicorum Upsaliensis.  (Uppsala, Sweden)  V.55-76,
   1950-71.  For publisher information, see UJMSAP.  Volume(issue)/page/year:
   73,199,1968
 
                            *** END OF RECORD ***