*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KG7676000 CHEMICAL NAME : Estra-1,3,5(10)-triene-3,4,17-beta-triol CAS REGISTRY NUMBER : 5976-61-4 LAST UPDATED : 199712 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H24-O3 MOLECULAR WEIGHT : 288.42 COMPOUND DESCRIPTOR : Tumorigen Mutagen Reproductive Effector SYNONYMS/TRADE NAMES : * 4-Hydroxyestradiol * 4-Hydroxy-17-beta-estradiol * 4-OH-Estradiol *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 900 mg/kg/90D-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1969- Volume(issue)/page/year: 24,353,1986 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 1280 ng/kg SEX/DURATION : male 8 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male Endocrine - androgenic REFERENCE : ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 23,339,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 10 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 42,165,1986 ** MUTATION DATA ** TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - hamster DOSE/DURATION : 14 mg/kg/7D (Continuous) REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,997,1994 *** END OF RECORD ***