*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KG7962400
CHEMICAL NAME           : Estr-4-en-3-one,
                          17-((((2-chloroethyl)nitrosoamino)carbonyl)oxy)-,
                          (17-beta)-
CAS REGISTRY NUMBER     : 54025-36-4
LAST UPDATED            : 198602
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H29-Cl-N2-O4
MOLECULAR WEIGHT        : 408.97
COMPOUND DESCRIPTOR     : Drug
                          Hormone
SYNONYMS/TRADE NAMES :
   * (17-beta)-17-((((2-Chloroethyl)nitrosoamino)carbonyl)oxy)estr-4-en-3-one
   * LEO 1727
   * LS 1727
   * 19-Nortestosterone-17/N-(2-chloroethyl)-N-nitrosocarbamate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2190 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - gastritis
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   49,290,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - gastritis
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   49,290,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Gastrointestinal - gastritis
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   49,290,1981
 
TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1630 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   49,290,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 98 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - peritonitis
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   49,290,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Gastrointestinal - gastritis
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   49,290,1981
 
                            *** END OF RECORD ***