*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KH6475000
CHEMICAL NAME : Ethane, bromo-
CAS REGISTRY NUMBER : 74-96-4
LAST UPDATED : 199712
DATA ITEMS CITED : 49
MOLECULAR FORMULA : C2-H5-Br
MOLECULAR WEIGHT : 108.98
WISWESSER LINE NOTATION : E2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Bromic ether
* Bromoethane
* Bromure d'ethyle
* Ethyl bromide
* Etylu bromek
* Halon 2001
* Hydrobromic ether
* Monobromoethane
* NCI-C55481
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,65,1982
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26980 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag,
Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1834-
Volume(issue)/page/year: 320,133,1978
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 16230 ppm/1H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag,
Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1834-
Volume(issue)/page/year: 320,133,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 pph/6H/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,1989
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1600 ppm/6H/14W-I
TOXIC EFFECTS :
Blood - changes in spleen
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,1989
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 pph/6H/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,1989
** TUMORIGENIC DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,1989
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,1989
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 75 ng/plate
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,1989
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
13,60,1989
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 22 mg/m3 (5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,299,1991
IARC Cancer Review:Human No Available Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,299,1991
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 52,299,1991
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (890 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,105,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (890 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 200 ppm (890 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (890 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (890 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (890 mg/m3);STEL 250 ppm (1110 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 200 ppm (890 mg/m3) JAN 1993
OEL-BELGIUM:TWA 200 ppm (891 mg/m3);STEL 250 ppm (1100 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (890 mg/m3) JAN 1993
OEL-FINLAND:TWA 200 ppm (890 mg/m3);STEL 250 ppm (1115 mg/m3) JAN 1993
OEL-FRANCE:TWA 288 ppm (890 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (890 mg/m3) JAN 1993
OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 200 ppm (890 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 300 ppm (890 mg/m3) JAN 1993
OEL-POLAND:TWA 50 mg/m3 JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (890 mg/m3);STEL 1000 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (890 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (890 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 31900
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 196 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 31900
No. of Facilities: 1452 (estimated)
No. of Industries: 15
No. of Occupations: 13
No. of Employees: 12285 (estimated)
No. of Female Employees: 1535 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Ethyl bromide, 1011
NTP Carcinogenesis Studies (inhalation);clear evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,89
NTP Carcinogenesis Studies (inhalation);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-363,89
*** END OF RECORD ***