*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KH8587085
CHEMICAL NAME           : 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 38260-01-4
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C6-H18-N4.2Cl-H
MOLECULAR WEIGHT        : 219.20
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * N,N'-Bis(2-aminoethyl)-1,2-ethanediamine dihydrochloride
   * 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, dihydrochloride
   * 2,2'-Ethylenediiminobis(ethylamine) dihydrochloride
   * MK-0681
   * Syprine
   * Trien dihydrochloride
   * Trientine hydrochloride
   * Triethylene tetramine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2285 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   (Suppl),246,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67500 mg/kg/90D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Liver - fatty liver degeneration
   Blood - changes in spleen
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   29,185,1996
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1140 uL/kg
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   JNSVA5 Journal of Nutritional Science and Vitaminology.  (Business Center
   for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)  V.19-
   1973-  Volume(issue)/page/year: 38,545,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 22800 mg/kg
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   JNSVA5 Journal of Nutritional Science and Vitaminology.  (Business Center
   for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)  V.19-
   1973-  Volume(issue)/page/year: 39,177,1993
 
                            *** END OF RECORD ***