*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KH7650000
CHEMICAL NAME           : Ethane, 1-chloro-1,1-difluoro-
CAS REGISTRY NUMBER     : 75-68-3
BEILSTEIN REFERENCE NO. : 1731584
REFERENCE               : 4-01-00-00127 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C2-H3-Cl-F2
MOLECULAR WEIGHT        : 100.50
WISWESSER LINE NOTATION : GXFF
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * CFC 142b
   * 1-Chloro-1,1-difluoroethane
   * Chloroethylidene fluoride
   * alpha-Chloroethylidene fluoride
   * 1,1-Difluoro-1-chloroethane
   * FC142b
   * Fluorocarbon FC142b
   * Freon 142
   * Freon 142b
   * Genetron 101
   * Genetron 142b
   * Gentron 142B
   * Hydrochlorofluorocarbon 142b
   * Isotron 142b
   * Monochlorodifluoroethane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2050 gm/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,53,1982
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1758 gm/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,53,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 gm/m3/4H/4W-I
TOXIC EFFECTS :
   Endocrine - evidence of thyroid hypofunction
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 9,175,1967
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 pph/16H/9D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Related to Chronic Data - death
REFERENCE :
   AIHOAX Archives of Industrial Hygiene and Occupational Medicine.  (Chicago,
   IL)  V.1-2(3), 1950.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 2(3),335,1950
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1000 ppm/6H
SEX/DURATION            : female 3-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0555347
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 pph/24H
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   72,15,1984

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-GERMANY:TWA 1000 ppm (4170 mg/m3) JAN 1993
   
   OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993
   
   OEL-RUSSIA:STEL 3000 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82201
       No. of Facilities: 11 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 357 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***