*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KI3280000 CHEMICAL NAME : 1,2-Ethanedisulfonic acid, compd. with 5-(2-chloroethyl)-4-methylthiazole (1:2) CAS REGISTRY NUMBER : 1867-58-9 LAST UPDATED : 199706 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C6-H8-Cl-N-S.1/2C2-H6-O6-S2 MOLECULAR WEIGHT : 256.74 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Chlormethiazole edisylate * Chlormethiazole ethanedisulfonate * 5-(2-Chloroethyl)-4-methylthiazole ethanedisulfonate (2:1) * Clomethiazole edisylate * Clomethiazole ethanedisulfonate * Heminevrin * Hemithiamine * SCTZ * Thiazole, 5-(2-chloroethyl)-4-methyl-, ethanedisulfonate (2:1) *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 1560 mg/kg/4D-C TOXIC EFFECTS : Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 10,315,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 835 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,269,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Behavioral - sleep REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,657,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,269,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,269,1967 *** END OF RECORD ***