*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KH8008500 CHEMICAL NAME : Ethane, 2-chloro-1,1,1-trifluoro- CAS REGISTRY NUMBER : 75-88-7 BEILSTEIN REFERENCE NO. : 1733200 REFERENCE : 4-01-00-00128 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C2-H2-Cl-F3 MOLECULAR WEIGHT : 118.49 COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * CFC 133a * 1-Chloro-2,2,2-trifluoroethane * 2-Chloro-1,1,1-trifluoroethane * FC 133a * Freon 133a * Genetron 133a * R 133a * 1,1,1-Trifluoro-2-chloroethane * 2,2,2-Trifluorochloroethane * 1,1,1-Trifluoroethyl chloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 pph/1H TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold REFERENCE : BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year: 37,716,1965 TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 33000 ppm/5H TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - acute pulmonary edema REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530594 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10 pph/1H/25D-I TOXIC EFFECTS : Behavioral - general anesthetic Liver - fatty liver degeneration Kidney, Ureter, Bladder - interstitial nephritis REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528422 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 78 gm/kg/1Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - testicular tumors Reproductive - Tumorigenic effects - uterine tumors REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,15,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,253,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,253,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***