*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KJ3750000
CHEMICAL NAME           : Ethane, trichloroepoxy-
CAS REGISTRY NUMBER     : 16967-79-6
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C2-H-Cl3-O
MOLECULAR WEIGHT        : 147.38
WISWESSER LINE NOTATION : T3OTJ BG BG CG
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Epoxy-1,1,2-trichloroethane
   * Oxirane, trichloro-
   * TCEO
   * 1,1,2-Trichloroepoxyethane
   * Trichloroethylene epoxide
   * Trichloroethylene oxide
   * Trichloro-oxirane
   * Trichlorooxirane
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,159,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 6 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 101,115,1982
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 500 umol/L
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
   Springer-Verlag, 1980  Volume(issue)/page/year: -,333,1980
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 1100 umol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 69,531,1982
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 50 umol/L
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin,
   Springer-Verlag, 1980  Volume(issue)/page/year: -,333,1980

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***