*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KK1750000
CHEMICAL NAME           : Ethanol, 2-((2-chloroethyl)thio)-
CAS REGISTRY NUMBER     : 693-30-1
BEILSTEIN REFERENCE NO. : 1697572
REFERENCE               : 4-01-00-02430 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C4-H9-Cl-O-S
MOLECULAR WEIGHT        : 140.64
WISWESSER LINE NOTATION : Q2S2G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * beta-Chloroethyl beta-hydroxyethyl sulfide
   * 2-Chloroethyl 2-hydroxyethyl sulfide
   * 2-((2-Chloroethyl)thio)ethanol
   * Half mustard gas
   * Half sulfur mustard
   * 2-Hydroxyethyl 2-chloroethyl sulfide
   * Mustard chlorohydrin
   * Sulfide, 2-chloroethyl 2-hydroxyethyl
   * Sulfur half-mustard
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB158-507
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Endocrine - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,1,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,1,1948
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   IUSMDJ ICN-UCLA Symposia on Molecular and Cellular Biology.  (Menlo Park,
   CA)  V.1-23, 1974-81.  Volume(issue)/page/year: 9,41,1979
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   IUSMDJ ICN-UCLA Symposia on Molecular and Cellular Biology.  (Menlo Park,
   CA)  V.1-23, 1974-81.  Volume(issue)/page/year: 9,41,1979
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   80,496,1961
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 4 mg/kg
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   80,496,1961
 
                            *** END OF RECORD ***