*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KK1750000 CHEMICAL NAME : Ethanol, 2-((2-chloroethyl)thio)- CAS REGISTRY NUMBER : 693-30-1 BEILSTEIN REFERENCE NO. : 1697572 REFERENCE : 4-01-00-02430 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C4-H9-Cl-O-S MOLECULAR WEIGHT : 140.64 WISWESSER LINE NOTATION : Q2S2G COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * beta-Chloroethyl beta-hydroxyethyl sulfide * 2-Chloroethyl 2-hydroxyethyl sulfide * 2-((2-Chloroethyl)thio)ethanol * Half mustard gas * Half sulfur mustard * 2-Hydroxyethyl 2-chloroethyl sulfide * Mustard chlorohydrin * Sulfide, 2-chloroethyl 2-hydroxyethyl * Sulfur half-mustard *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-507 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - hepatitis (hepatocellular necrosis), diffuse Endocrine - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,1,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,1,1948 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Human HeLa cell DOSE/DURATION : 1500 mg/L REFERENCE : IUSMDJ ICN-UCLA Symposia on Molecular and Cellular Biology. (Menlo Park, CA) V.1-23, 1974-81. Volume(issue)/page/year: 9,41,1979 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human HeLa cell DOSE/DURATION : 1500 mg/L REFERENCE : IUSMDJ ICN-UCLA Symposia on Molecular and Cellular Biology. (Menlo Park, CA) V.1-23, 1974-81. Volume(issue)/page/year: 9,41,1979 TYPE OF TEST : DNA adduct TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 umol/L REFERENCE : BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 80,496,1961 TYPE OF TEST : DNA adduct TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 4 mg/kg REFERENCE : BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 80,496,1961 *** END OF RECORD ***