*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KK2450000
CHEMICAL NAME : Ethanol, 2-chloro-, phosphate (3:1)
CAS REGISTRY NUMBER : 115-96-8
BEILSTEIN REFERENCE NO. : 1710938
REFERENCE : 4-01-00-01379 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 26
MOLECULAR FORMULA : C6-H12-Cl3-O4-P
MOLECULAR WEIGHT : 285.50
WISWESSER LINE NOTATION : G2OPO&O2GO2G
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Antiblaze 100
* Celluflex
* 2-Chloroethanol phosphate
* Fyrol CEF
* NCI-C60128
* Niax flame retardant 3 CF
* Phosphoric acid, tris(2-chloroethyl)ester
* Trichlorethyl phosphate
* Tri-beta-chloroethyl phosphate
* Tri(2-chloroethyl)phosphate
* Tris-(2-chlorethyl)fosfat
* Tris(beta-chloroethyl) phosphate
* Tris(2-chloroethyl) phosphate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 17,720,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1866 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A067-313
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 7,396,1955
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0517716
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2100 mg/kg/16D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-391,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28 gm/kg/16W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
6,1,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 56 gm/kg/16W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
6,1,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 56 gm/kg/16W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:
6,1,1990
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45760 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-391,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 182 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-391,1991
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1800 mg/kg
SEX/DURATION : female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(101),55,1983
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,373,1979
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 125 mg/kg
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)-
25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year:
18,1337,1982
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 400 mg/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)-
25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year:
18,1337,1982
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 700 mg/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)-
25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year:
18,1337,1982
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 48,109,1990
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 48,109,1990
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 17,101,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0756
No. of Facilities: 95 (estimated)
No. of Industries: 5
No. of Occupations: 9
No. of Employees: 762 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0756
No. of Facilities: 278 (estimated)
No. of Industries: 6
No. of Occupations: 5
No. of Employees: 5073 (estimated)
No. of Female Employees: 578 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (gavage);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTR-TR-391,91
NTP Carcinogenesis Studies (gavage);equivocal evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-391,91
*** END OF RECORD ***