*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KK7400000
CHEMICAL NAME           : Ethanol, 2,2'-((4,5-diphenyl-2-oxazolyl)imino)di-,
                          monohydrate
CAS REGISTRY NUMBER     : 63867-52-7
LAST UPDATED            : 199007
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H20-N2-O3.H2-O
MOLECULAR WEIGHT        : 342.43
WISWESSER LINE NOTATION : T5N COJ BN2Q2Q DR& ER &QH
SYNONYMS/TRADE NAMES :
   * Ageroplas
   * 2-(Bis(beta-hydroxyethyl)amino)-4,5-diphenyloxazole monohydrate
   * Diethamphenazol monohydrate
   * 2,2'-Dihydroxy-N-(4,5-diphenyloxazole-2-yl)diethylamine monohydrate
   * N-(4,5-Diphenyloxazol-2-yl)diethanolamine monohydrate
   * 2,2'-((4,5-Diphenyl-2-oxazolyl)imino)-diethanol monohydrate
   * Ditazol monohydrate
   * S 222
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11380 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1283,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7770 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1283,1973
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 11,1092,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3390 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1283,1973
 
                            *** END OF RECORD ***