*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KK8925000 CHEMICAL NAME : Ethanol, 2-(2-ethoxyethoxy)-, acetate CAS REGISTRY NUMBER : 112-15-2 BEILSTEIN REFERENCE NO. : 1764643 REFERENCE : 3-02-00-00308 (Beilstein Handbook Reference) LAST UPDATED : 199712 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C8-H16-O4 MOLECULAR WEIGHT : 176.24 WISWESSER LINE NOTATION : 2O2O2OV1 COMPOUND DESCRIPTOR : Primary Irritant SYNONYMS/TRADE NAMES : * Acetic acid 2-(2-ethoxyethoxy)ethyl ester * Carbitol acetate * Diethylene glycol monoethyl ether acetate * Diglycol monoethyl ether acetate * Ektasolve de acetate * 2-(2-Ethoxyethoxy)ethanol acetate * 2-(2-Ethoxyethoxy)ethyl acetate * 2-(2-Ethoxyethoxy)ethylester kyseliny octove * Glycol ether de acetate * Karbitolacetat *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Open irritation test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg REACTION SEVERITY : Mild REFERENCE : UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/20/1965 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg REACTION SEVERITY : Moderate REFERENCE : AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/20/1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4027,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 15100 uL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/20/1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3930 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 96 gm/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 480 mg/m3/6H/2W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533831 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 04580 No. of Facilities: 2487 (estimated) No. of Industries: 32 No. of Occupations: 25 No. of Employees: 19983 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 04580 No. of Facilities: 1829 (estimated) No. of Industries: 28 No. of Occupations: 28 No. of Employees: 18136 (estimated) No. of Female Employees: 4675 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***