*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KJ4552000
CHEMICAL NAME           : 9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl-
CAS REGISTRY NUMBER     : 10262-69-8
BEILSTEIN REFERENCE NO. : 2385493
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C20-H23-N
MOLECULAR WEIGHT        : 277.44
WISWESSER LINE NOTATION : L6 H666/GP 2AF P&&TTJ O3M1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 276-Ba
   * 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)propylmethylamine
   * Maprotiline
   * Maprotylina
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,260,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 40,235,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 40,235,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5760 mg/kg/22W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Related to Chronic Data - death
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1709,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/kg/7W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   51,43,1982
 
                            *** END OF RECORD ***