*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KL9275000
CHEMICAL NAME : Ethanol, 2,2',2''-nitrilotri-
CAS REGISTRY NUMBER : 102-71-6
LAST UPDATED : 199712
DATA ITEMS CITED : 32
MOLECULAR FORMULA : C6-H15-N-O3
MOLECULAR WEIGHT : 149.22
WISWESSER LINE NOTATION : Q2N2Q2Q
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Alkanolamine 244
* Daltogen
* Nitrilo-2,2',2''-triethanol
* 2,2',2''-Nitrilotriethanol
* Sterolamide
* Sting-Kill
* TEA (amino alcohol)
* Thiofaco T-35
* Triaethanolamin-NG
* Triethanolamin
* Triethanolamine
* Triethanolamine
* Triethylamine, 2,2',2''-trihydroxy-
* Triethylolamine
* Tri(hydroxyethyl)amine
* Trihydroxytriethylamine
* Tris(2-hydroxyethyl)amine
* Trolamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 15 mg/3D (Intermittent)
REACTION SEVERITY : Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 560 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
19,276,1971
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg
REACTION SEVERITY : Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
55,501,1980
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4920 uL/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >16 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5846 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - other changes
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCRVAB Russian Chemical Reviws (English Translation). Translation of
USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd.,
Letchworth, Herts SG6 1HN, UK) V.29- 1960- Volume(issue)/page/year:
38,975,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,114,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/18/1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,114,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520710
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 63028 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520455
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 96 gm/kg/60D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516740
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 29700 ug/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/m3/6H/3W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in thymus weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533592
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 125 mg/m3/6H/3W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533591
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 192 gm/kg/17W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516740
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 32 gm/kg/4D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516740
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
Volume(issue)/page/year: 39,422,1986
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1 mmol/L
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 21(6),29,1987
*** REVIEWS ***
ACGIH TLV-TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-SWEDEN:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0260
No. of Facilities: 61500 (estimated)
No. of Industries: 297
No. of Occupations: 201
No. of Employees: 821293 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0260
No. of Facilities: 70726 (estimated)
No. of Industries: 311
No. of Occupations: 195
No. of Employees: 1726272 (estimated)
No. of Female Employees: 573604 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NTP Carcinogenesis studies; test completed (post peer review), October 1997
*** END OF RECORD ***