*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KM0350000
CHEMICAL NAME : Ethanol, 2-phenoxy-
CAS REGISTRY NUMBER : 122-99-6
BEILSTEIN REFERENCE NO. : 1364011
REFERENCE : 4-06-00-00571 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C8-H10-O2
MOLECULAR WEIGHT : 138.18
WISWESSER LINE NOTATION : Q2OR
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Arosol
* Dowanol EP
* Dowanol EPH
* Emeressence 1160
* Emery 6705
* Ethylene glycol monophenyl ether
* Ethylene glycol phenyl ether
* 2-Fenoxyethanol
* Fenyl-cellosolve
* Fenylcelosolv
* Glycol monophenyl ether
* beta-Hydroxyethyl phenyl ether
* 1-Hydroxy-2-phenoxyethane
* Phenoxethol
* Phenoxetol
* Phenoxyethanol
* 2-Phenoxyethanol
* Phenoxyethyl alcohol
* Phenoxytol
* Phenyl cellosolve
* Phenylmonoglycol ether
* Rose ether
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,637,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6 mg
REACTION SEVERITY : Moderate
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/24/1958
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 250 ug/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,637,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1260 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14422 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 9,259,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 554 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (3),37,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 933 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (3),37,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 490 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (3),37,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/24/1958
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 182 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 9(2),259,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17500 mg/kg/14D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion
Blood - other changes
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0531470
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/m3/9W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - somnolence (general depressed activity)
Liver - liver function tests impaired
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (3),37,1996
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3 gm/kg/10D-I
TOXIC EFFECTS :
Behavioral - general anesthetic
Kidney, Ureter, Bladder - other changes in urine composition
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0531470
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 14 gm/kg/14D-I
TOXIC EFFECTS :
Blood - other changes
Related to Chronic Data - death
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 9(2),259,1990
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2000 ppm
REFERENCE :
MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 28,7,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2000 ppm
REFERENCE :
MCBIA7 Microbios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 28,7,1980
*** REVIEWS ***
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
13,747,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83449
No. of Facilities: 711 (estimated)
No. of Industries: 18
No. of Occupations: 19
No. of Employees: 9560 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83449
No. of Facilities: 5523 (estimated)
No. of Industries: 63
No. of Occupations: 77
No. of Employees: 111040 (estimated)
No. of Female Employees: 46637 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***