*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KM5600000 CHEMICAL NAME : Ethanone, 1-(4-chlorophenyl)- CAS REGISTRY NUMBER : 99-91-2 BEILSTEIN REFERENCE NO. : 0386014 REFERENCE : 4-07-00-00639 (Beilstein Handbook Reference) LAST UPDATED : 199709 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C8-H7-Cl-O MOLECULAR WEIGHT : 154.60 WISWESSER LINE NOTATION : GR DV1 COMPOUND DESCRIPTOR : Human SYNONYMS/TRADE NAMES : * Acetophenone, 4'-chloro- * p-Acetylchlorobenzene * 4-Acetylchlorobenzene * 4'-Chloroacetophenone * 1-(4-Chlorophenyl)ethanone * p-Chlorophenyl methyl ketone * 4-Chlorophenyl methyl ketone * Methyl p-chlorophenyl ketone * Methyl 4-chlorophenyl ketone * USAF DO-1 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 1 mg/m3/1M TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - effect, not otherwise specified REFERENCE : 27ZZA9 "Manual of Pharmacology and Its Applications to Therapeutics and Toxicology," 8th ed., Sollman, T., Philadelphia, W.B. Saunders Co., 1957 Volume(issue)/page/year: 8,192,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1207 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,317,1976 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1752 mg/m3/15M TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 14,411,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 87600 ug/m3/15M/10D-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Endocrine - hyperglycemia Endocrine - changes in spleen weight REFERENCE : JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 14,411,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7067 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***