*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KN3525000
CHEMICAL NAME           : Ether, bis(pentabromophenyl)
CAS REGISTRY NUMBER     : 1163-19-5
BEILSTEIN REFERENCE NO. : 2188438
REFERENCE               : 1-06-00-00108 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 16
MOLECULAR FORMULA       : C12-Br10-O
MOLECULAR WEIGHT        : 959.22
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Benzene, 1,1'-oxybis(2,3,4,5,6-pentabromo-
   * Berkflam B 10E
   * Bis(pentabromophenyl)ether
   * BR 55N
   * Bromkal 83-10DE
   * Bromkal 82-ode
   * Dbdpo
   * Decabrom
   * Decabromobiphenyl ether
   * Decabromobiphenyl oxide
   * Decabromodiphenyl ether
   * Decabromodiphenyl oxide
   * Decabromophenyl ether
   * De 83R
   * Ether, decabromodiphenyl
   * FR 300
   * FR 300BA
   * FRP 53
   * NCI-C55287
   * 1,1'-Oxybis(2,3,4,5,6-pentabromobenzene)
   * Pentabromophenyl ether
   * Saytex 102
   * Saytex 102E
   * Tardex 100
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 uL
REACTION SEVERITY       : Severe
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0522261
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0522261
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 48(8),18,1983
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 24 gm/kg/30D-C
TOXIC EFFECTS :
   Liver - other changes
   Endocrine - thyroid weight (goiter)
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 11,153,1975
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1092 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-309,1986
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   COTODO Journal of Fire and Flammability/Combustion Toxicology Supplement.
   (Westport, CT)  V.1-2, 1974-75.  For publisher information, see JCTODH.
   Volume(issue)/page/year: 1,52,1974

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,73,1990

   IARC Cancer Review:Group 3
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 48,73,1990

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 3 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X4046
       No. of Facilities: 981 (estimated)
       No. of Industries: 12
       No. of Occupations: 30
       No. of Employees: 32661 (estimated)
       No. of Female Employees: 8875 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NTP Carcinogenesis Studies (feed);some evidence:rat
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-309,86

   NTP Carcinogenesis Studies (feed);equivocal evidence:mouse
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-309,86

 
                            *** END OF RECORD ***