*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KQ7600000
CHEMICAL NAME           : Ethylamine, 2-(o-benzylphenoxy)-N,N-dimethyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 6152-43-8
LAST UPDATED            : 199107
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H21-N-O.Cl-H
MOLECULAR WEIGHT        : 291.85
WISWESSER LINE NOTATION : 1N1&2OR B1R &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bristamin hydrochloride
   * N-(2'-Dimethylaminoaethyl)-(o-benzylphenol)-aether hydrochlorid
   * (2-(Dimethylamino)ethyl) (o-benzylphenoxy)ether hydrochloride
   * N,N-Dimethyl-2-(alpha-phenyl-o-toloxy)-ethylamine hydrochloride
   * Ethylamine, N,N-dimethyl-2-((alpha-phenyl-o-tolyl)oxy)-, hydrochloride
   * HL 2153
   * Phenyltoloxamine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 305 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,219,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 163 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 42,587,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 42,587,1953
 
                            *** END OF RECORD ***