*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KR7175000
CHEMICAL NAME           : Ethylamine, 2,2'-dithiobis-
CAS REGISTRY NUMBER     : 51-85-4
BEILSTEIN REFERENCE NO. : 1736027
REFERENCE               : 4-04-00-01577 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C4-H12-N2-S2
MOLECULAR WEIGHT        : 152.30
WISWESSER LINE NOTATION : Z2SS2Z
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Becaptan disulfure
   * Bis(beta-aminoethyl)disulfide
   * Cystamine
   * Cysteinamine disulfide
   * Cystinamin
   * Cystineamine
   * Decarboxycystine
   * beta,beta'-Diaminodiethyl disulfide
   * 2,2'-Dithiobis(ethylamine)
   * 1591 L
   * Mercamine disulfide
   * beta-Mercaptoethylamine disulfide
   * 2-Mercaptoethylamine (oxidized)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 99 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SVLKAO Sbornik Vedeckych Praci Lekarske Fakulty Univerzity Karlovy v Hradci
   Kralove.  Collection of Scientific Works of the Charles University Faculty
   of Medicine in Hradec Kralove.  (Univerzita Karlova, Ovocny Trh.3, 116-36
   Prague 1, Czechoslovakia)  V.1-    1958-  Volume(issue)/page/year:
   24,541,1981
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 185,461,1937
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   SVLKAO Sbornik Vedeckych Praci Lekarske Fakulty Univerzity Karlovy v Hradci
   Kralove.  Collection of Scientific Works of the Charles University Faculty
   of Medicine in Hradec Kralove.  (Univerzita Karlova, Ovocny Trh.3, 116-36
   Prague 1, Czechoslovakia)  V.1-    1958-  Volume(issue)/page/year:
   24,541,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RDBGAT Radiobiologia, Radiotherapia.  (Buchexport, Postfach 160, Leipzig
   DDR-7010, Ger. Dem. Rep.) V.1-    1960-  Volume(issue)/page/year:
   19,593,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 109,108,1957
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 185,461,1937
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 185,461,1937
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 200 mmol/L
REFERENCE :
   IJRBA3 International Journal of Radiation Biology and Related Studies in
   Physics, Chemistry and Medicine.  (Taylor & Francis Inc., 242 Cherry St.,
   Philadelphia, PA 19106)  V.1-    1959-  Volume(issue)/page/year: 9,185,1965
 
                            *** END OF RECORD ***