*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KR9770000
CHEMICAL NAME           : Ethylamine, 2-(1-piperidino)-2-(2-thenyl)-, maleate
CAS REGISTRY NUMBER     : 63918-29-6
LAST UPDATED            : 199107
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C11-H18-N2-S.C4-H4-O4
MOLECULAR WEIGHT        : 326.45
WISWESSER LINE NOTATION : T6NTJ AY1Z- BT5SJ &OV1U1VO
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ciba Go. 2825
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1483 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 93 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 647 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 116 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 243 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 690 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JETOAS Journal Europeen de Toxicologie.  (Paris, France)  V.1-6, 1968-72.
   For publisher information, see TOERD9.  Volume(issue)/page/year: 3,110,1970
 
                            *** END OF RECORD ***