*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KV9360000
CHEMICAL NAME : Ethylene, 1,2-dichloro-
CAS REGISTRY NUMBER : 540-59-0
BEILSTEIN REFERENCE NO. : 1719345
REFERENCE : 2-01-00-00158 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 38
MOLECULAR FORMULA : C2-H2-Cl2
MOLECULAR WEIGHT : 96.94
WISWESSER LINE NOTATION : G1U1G
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetylene dichloride
* 1,2-Dichlor-aethen
* 1,2-Dichloroethene
* Dichloro-1,2-ethylene
* sym-Dichloroethylene
* 1,2-Dichloroethylene
* Dioform
* NCI-C56031
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,105,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,10,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,247,1974
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 117 mg/m3/1H
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AISFAR Archivio Italiano di Scienze Farmacologiche. (Modena, Italy) V.1-11,
1932-42; Series 2: V.1-3, 1948-50; Series 3: V.1-15, 1951-65. Discontinued.
Volume(issue)/page/year: 15,1,1937
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 750 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 266,117,1992
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 20 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,185,1996
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,185,1996
*** REVIEWS ***
ACGIH TLV-TWA 793 mg/m3 (200 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (790 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,80,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (790 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 200 ppm (790 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (790 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (790 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-BELGIUM:TWA 200 ppm (793 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-FINLAND:TWA 200 ppm (790 mg/m3);STEL 250 ppm (990 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-HUNGARY:TWA 80 mg/m3;STEL 160 mg/m3 JAN 1993
OEL-JAPAN:TWA 150 ppm (590 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-POLAND:TWA 50 mg/m3 JAN 1993
OEL-RUSSIA:TWA 150 ppm JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (790 mg/m3);STEL 400 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (790 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (790 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 1,2-DICHLOROETHYLENE-air:10H TWA 200 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 03350
No. of Facilities: 896 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 4673 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 03350
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 7
No. of Employees: 216 (estimated)
No. of Female Employees: 10 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NTP Carcinogenesis studies; test completed (peer review), October 1997
*** END OF RECORD ***