*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : KX1625000 CHEMICAL NAME : Ethylene isocyanide, bis(p-hydroxybenzylidene)- CAS REGISTRY NUMBER : 580-74-5 BEILSTEIN REFERENCE NO. : 3700094 REFERENCE : 4-13-00-02885 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H12-N2-O2 MOLECULAR WEIGHT : 288.32 WISWESSER LINE NOTATION : QR D1UYNU1&YNU1&U1R DQ COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * Brevicid * Brevicide * Brevicide-X * 1,4-Di-p-oxyphenyl-2,3-di-isonitrilo-1,3-butadien * Ophthocillin * Phenol, 4,4'-(2,3-diisocyano-1,3-butadiene-1,4-diyl)bis- * Trianthil * Xanthocillin * Xantyrid *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,98,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 21,217,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,98,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 21,217,1966 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay *** END OF RECORD ***