*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LF1575000
CHEMICAL NAME           : EX 10-542A
CAS REGISTRY NUMBER     : 31909-67-8
LAST UPDATED            : 199409
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 5-Benzyl-11-(4-(N-methylpiperidylene))-5,6-dihydromorphanthridine  
   hydrogen maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1596 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 9100 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of endocrine pancreas
   Liver - changes in liver weight
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,451,1971
 
                            *** END OF RECORD ***