*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KV2830000
CHEMICAL NAME           : Ethylenediamine,
                          N-(p-bromobenzyl)-N',N'-dimethyl-N-(2-pyridyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 14612-92-1
LAST UPDATED            : 198706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C16-H20-Br-N3.Cl-H
MOLECULAR WEIGHT        : 370.76
WISWESSER LINE NOTATION : T6NJ BN1R DE&2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   N-p-Brombenzyl-N-alpha-pyridyl-N',N'-dimethyl-aethylendiamin-hydrochlori
     de
   * N-p-Bromobenzyl-N',N'-dimethyl-N-2-pyridylethylenediamine hydrochloride
   * Bromobenzyl D.P.E. hydrochloride
   * N,N-Dimethyl-N'-(p-bromobenzyl)-N'-(2-pyridyl)ethylenediamine  
   hydrochloride
   * Hibernon hydrochloride
   * Pyridine, 2-((p-bromobenzyl)(2-(dimethylamino)ethyl)amino)-,  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 665 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 14,940,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 177 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   81,55,1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 183 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 14,940,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 14,940,1964
 
                            *** END OF RECORD ***