*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : KV0600000
CHEMICAL NAME           : Ethylene, chlorotris(p-methoxyphenyl)-
CAS REGISTRY NUMBER     : 569-57-3
BEILSTEIN REFERENCE NO. : 1891845
REFERENCE               : 4-06-00-07650 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C23-H21-Cl-O3
MOLECULAR WEIGHT        : 380.89
WISWESSER LINE NOTATION : 1OR DYGUYR DO1&R DO1
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Anisene
   * Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-
   * Chlorestrolo
   * 1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)
   * Chlorotrianisene
   * Chlorotrianizen
   * Chlorotrisin
   * Chlorotris(p-methoxyphenyl)ethylene
   * Chlortrianisen
   * Clorestrolo
   * Clorotrisin
   * CTA
   * Hormonisene
   * Khlortrianizen
   * Merbentul
   * Metace
   * NSC-10108
   * Rianil
   * TACE
   * Tace-Fn
   * Tri-p-anisylchloroethylene
   * Tris(p-methoxyphenyl)chloroethylene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 37 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,489,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg/89W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   AMPLAO AMA Archives of Pathology.  (Chicago, IL)  V.50(4)-69, 1950-60.  For
   publisher information, see APLMAS.  Volume(issue)/page/year: 50,750,1950
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 48 mg/kg
SEX/DURATION            : female 14 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   OBGNAS Obstetrics and Gynecology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1953- Volume(issue)/page/year:
   8,399,1956

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 21,139,1979

   TOXICOLOGY REVIEW
   ACRSAJ Advances in Cancer Research.  (Academic Press, Inc., 465 S. Lincoln
   Dr., Troy, MO 63379) V.1-    1953-  Volume(issue)/page/year: 1,173,1953

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84523
       No. of Facilities: 14 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 1134 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84523
       No. of Facilities: 18 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 229 (estimated)
       No. of Female Employees: 114 (estimated)

 
                            *** END OF RECORD ***