*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LM5075000
CHEMICAL NAME           : Fluorescein
CAS REGISTRY NUMBER     : 2321-07-5
BEILSTEIN REFERENCE NO. : 0094324
REFERENCE               : 5-19-06-00456 (Beilstein Handbook Reference)
LAST UPDATED            : 199707
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C20-H12-O5
MOLECULAR WEIGHT        : 332.32
WISWESSER LINE NOTATION : T C666 BO EVJ IR BVQ& MQ
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
   * 9-(o-Carboxyphenyl)-6-hydroxy-3-isoxanthenone
   * 9-(o-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one
   * C.I. 45350:1
   * C.I. 45350A
   * C.I. 45350 (free acid)
   * C.I. Solvent Yellow 94
   * D+C Yellow No. 7
   * 3',6'-Dihydroxyfluoran
   * Dihydroxyfluorane
   * 3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'(9H)-xanthen)-3-one
   * Fluoran, 3',6'-dihydroxy-
   * 3,6-Fluorandiol
   * 3',6'-Fluorandiol
   * Fluoresceine
   * Hidacid fluorescein
   * Resorcinolphthalein
   * Soap Yellow F
   * 3H-Xanthen-3-one, 9-(o-carboxyphenyl)-6-hydroxy-
   * 11712 Yellow
   * Zlut kysela 73
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJLEAG International Journal of Leprosy and Other Mycobacterial Diseases.
   (POB 1097, Bloomfield, NJ 07003)  V.1-    1933-  Volume(issue)/page/year:
   2,257,1934
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4775625
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJLEAG International Journal of Leprosy and Other Mycobacterial Diseases.
   (POB 1097, Bloomfield, NJ 07003)  V.1-    1933-  Volume(issue)/page/year:
   2,257,1934
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 15 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 33350
       No. of Facilities: 495 (estimated)
       No. of Industries: 18
       No. of Occupations: 21
       No. of Employees: 5188 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 33350
       No. of Facilities: 2171 (estimated)
       No. of Industries: 42
       No. of Occupations: 55
       No. of Employees: 88495 (estimated)
       No. of Female Employees: 21558 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***