*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LM5250000
CHEMICAL NAME           : Fluorescein, 2',7'-dibromo-4'-(hydroxymercurio)-,
                          disodium salt
CAS REGISTRY NUMBER     : 129-16-8
LAST UPDATED            : 199710
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C20-H8-Br2-Hg-O6.2Na
MOLECULAR WEIGHT        : 750.67
WISWESSER LINE NOTATION : T C666 BO EVJ D-HG-Q FE IR BVQ& LE MQ &-NA- 2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Asceptichrome
   * Aseptichrome
   * Chromargyre
   * 2,7-Dibromo-4-hydroxymercurifluoresceine disodium salt
   * Disodium 2,7-dibrom-4-hydroxy-mercuri-fluorescein
   * Disodium 2',7'-dibromo-4'-(hydroxymercury)fluorescein
   * DOMF
   * Flavurol
   * Fluorochrome
   * Gallochrome
   * Gynochrome
   * Merbromin
   * Mercuranine
   * Mercurochrome
   * Mercurochrome-220 soluble
   * Mercurocol
   * Mercurome
   * Mercurophage
   * Planochrome
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 43,71,1931
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie.  (Vienna,
   Austria)  V.1-108, 1867-1974.  For publisher information, see LROTDW.
   Volume(issue)/page/year: 73,751,1939
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 43,645,1931
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 35,343,1929
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mg/L
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 31,97,1979
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 mg/L
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 31,97,1979

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   SDGTB3 Seminars in Drug Treatment.  (New York, NY)  V.1-3, 1971-74.
   Discontinued.  Volume(issue)/page/year: 1,177,1971

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 44650
       No. of Facilities: 586 (estimated)
       No. of Industries: 5
       No. of Occupations: 10
       No. of Employees: 7896 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 44650
       No. of Facilities: 372 (estimated)
       No. of Industries: 3
       No. of Occupations: 6
       No. of Employees: 5294 (estimated)
       No. of Female Employees: 3955 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
   cerevisiae-aneuploidy
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***