*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LM5850000
CHEMICAL NAME : Fluorescein, 2',4',5',7'-tetrabromo-, disodium salt
CAS REGISTRY NUMBER : 17372-87-1
OTHER CAS REGISTRY NOS. : 12777-83-2
1340-15-4
122199-14-8
95917-83-2
37361-24-3
84932-33-2
LAST UPDATED : 199806
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C20-H8-Br4-O5.2Na
MOLECULAR WEIGHT : 693.90
WISWESSER LINE NOTATION : T C666 BO EVJ DE FE IR BVQ& LE MQ NE &-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acid Red 87
* Aizen Eosine GH
* Basacid Red 316
* Bromo acid
* Bromo B
* Bromo 4DC
* Bromo 4DL
* Bromoeosine
* Bromo FL
* Bromofluoresceic acid
* Bromo fluorescein
* Bromo JPS
* Bromo TS
* Bromo X-100
* Bromo XX
* Bronze Bromo
* Certiqual Eosine
* Cerven kysela 87
* C.I. 45380
* C.I. Acid Red 87
* D&C Red No. 22
* Disodium eosin
* Eosin
* Eosin A
* Eosine
* Eosine A
* Eosine BPC
* Eosine BS
* Eosine BS-SF
* Eosine DA
* Eosine DWC 73
* Eosine Extra Conc. A. Export
* Eosine Extra Yellowish
* Eosine FA
* Eosine G
* Eosine 3G
* Eosine GF
* Eosine J
* Eosine K
* Eosine K Salt Free
* Eosine OJ
* Eosine S13 (bluish)
* Eosine sodium salt
* Eosine w/s
* Eosine Y
* Eosine 3Y
* Eosine YB
* Eosine Yellowish
* Eosine Yellowish-(YS)
* Eosine YS
* Eosin G
* Eosin gelblich
* Eosin Y
* Eosin YS
* Fenazo Eoxine XG
* Hidacid Boiling Bromo
* Hidacid Bromo acid regular
* Hidacid Dibromo Fluorescein
* Hidacid Eosine Soda Salt
* Hidacid White Bromo
* Irgalite Bronze Red CL
* Phloxine Red 20-7600
* Japan Red 103
* Japan Red 230-1
* Morning red
* Orient Water Red 2
* Phloxine Toner B
* Phlox Red Toner X-1354
* Pure eosine YY
* Red No. 103
* Red No. 230-1
* 11445 Red
* 11731 Red
* Sodium eosinate
* Sodium eosine
* Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one,
2',4',5',7'-tetrabromo-3',6'-dihydroxy-, 2Na
* Symuler Eosin Toner
* Tetrabromofluorescein
* Tetrabromofluorescein D
* 2',4',5',7'-Tetrabromofluorescein disodium salt
* Tetrabromofluorescein S
* Toyo Eosine G
* Water Red 2
* 1903 Yellow Pink
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJLEAG International Journal of Leprosy and Other Mycobacterial Diseases.
(POB 1097, Bloomfield, NJ 07003) V.1- 1933- Volume(issue)/page/year:
2,257,1934
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2344 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EAPHA6 Eastern Pharmacist. (507, Ashok Bhawan, 93, Neru Place, New Delhi
110 019, India) V.1- 1958- Volume(issue)/page/year: 24,125,1981
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJLEAG International Journal of Leprosy and Other Mycobacterial Diseases.
(POB 1097, Bloomfield, NJ 07003) V.1- 1933- Volume(issue)/page/year:
2,257,1934
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
46,367,1955
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
19(Suppl 21),2,1992
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 2 mg/disc
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
1949/50- Volume(issue)/page/year: 27,153,1976
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 15,183,1977
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1450
No. of Facilities: 2601 (estimated)
No. of Industries: 18
No. of Occupations: 28
No. of Employees: 24024 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1450
No. of Facilities: 4477 (estimated)
No. of Industries: 20
No. of Occupations: 29
No. of Employees: 59954 (estimated)
No. of Female Employees: 28062 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***