*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LM5900000
CHEMICAL NAME           : Fluorescein,
                          2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium
                          salt
CAS REGISTRY NUMBER     : 18472-87-2
OTHER CAS REGISTRY NOS. : 37361-25-4
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C20-H2-Br4-Cl4-O5.2Na
MOLECULAR WEIGHT        : 829.64
WISWESSER LINE NOTATION : T C666 BO EVJ DE FE IR BG CG DG EG FVO& LE MO NE
                          &-NA- 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Acid Red 92
   * Aizen Acid Phloxine PB
   * C.I. 45410
   * C.I. Acid Red 92
   * Cyanosin
   * Cyanosin (acid dye)
   * Cyanosine
   * D and C Red No. 28
   * Eosin Blue
   * Eosine Blue
   * Eosine bluish
   * Food Dye Red No. 104
   * Food Red No. 104
   * Japan Red 104
   * Orient Water Pink 2
   * Phloxin B
   * Phloxine B
   * Phloxine P
   * Red 104
   * 11969 Red
   * Red No. 104
   * 3427 Veri Pur Pink
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,225,1978
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75600 mg/kg/90W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Endocrine - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   32,517,1994
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 63 gm/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   SKEZAP Shokuhin Eiseigaku Zasshi.  Food Hygiene Journal.  (Nippon Shokuhin
   Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
   150, Japan)  V.1-    1960-  Volume(issue)/page/year: 16,34,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 39600 mg/kg
SEX/DURATION            : female 6-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,55,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 66 gm/kg
SEX/DURATION            : female 6-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,55,1984
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 3 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 30,239,1975

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M4129
       No. of Facilities: 301 (estimated)
       No. of Industries: 2
       No. of Occupations: 5
       No. of Employees: 1460 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M4129
       No. of Facilities: 559 (estimated)
       No. of Industries: 3
       No. of Occupations: 11
       No. of Employees: 9866 (estimated)
       No. of Female Employees: 3202 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X9003
       No. of Facilities: 636 (estimated)
       No. of Industries: 2
       No. of Occupations: 3
       No. of Employees: 8722 (estimated)
       No. of Female Employees: 6754 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
   reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***