*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : LM5900000 CHEMICAL NAME : Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium salt CAS REGISTRY NUMBER : 18472-87-2 OTHER CAS REGISTRY NOS. : 37361-25-4 LAST UPDATED : 199701 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C20-H2-Br4-Cl4-O5.2Na MOLECULAR WEIGHT : 829.64 WISWESSER LINE NOTATION : T C666 BO EVJ DE FE IR BG CG DG EG FVO& LE MO NE &-NA- 2 COMPOUND DESCRIPTOR : Tumorigen Mutagen Reproductive Effector SYNONYMS/TRADE NAMES : * Acid Red 92 * Aizen Acid Phloxine PB * C.I. 45410 * C.I. Acid Red 92 * Cyanosin * Cyanosin (acid dye) * Cyanosine * D and C Red No. 28 * Eosin Blue * Eosine Blue * Eosine bluish * Food Dye Red No. 104 * Food Red No. 104 * Japan Red 104 * Orient Water Pink 2 * Phloxin B * Phloxine B * Phloxine P * Red 104 * 11969 Red * Red No. 104 * 3427 Veri Pur Pink *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 310 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 44,225,1978 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75600 mg/kg/90W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - tumors REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 32,517,1994 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 63 gm/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 16,34,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 39600 mg/kg SEX/DURATION : female 6-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,55,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 66 gm/kg SEX/DURATION : female 6-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,55,1984 ** MUTATION DATA ** TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Human Lung DOSE/DURATION : 3 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 30,239,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4129 No. of Facilities: 301 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1460 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4129 No. of Facilities: 559 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9866 (estimated) No. of Female Employees: 3202 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9003 No. of Facilities: 636 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 8722 (estimated) No. of Female Employees: 6754 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine reversion-Ames test EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***