*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LM5920000
CHEMICAL NAME           : Fluorescein,
                          4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-, disodium
                          salt
CAS REGISTRY NUMBER     : 632-69-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C20-H2-Cl4-I4-O5.2Na
MOLECULAR WEIGHT        : 1017.60
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Food Red Color No. 105, sodium salt
   * Food Red No. 105, sodium salt
   * Rose bengal sodium
   * R105 sodium
   *   9-(3',4',5',6'-Tetrachloro-o-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-
     3-isoxanthone 2Na
   * 4,5,6,7-Tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 707 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 77,277,1986
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 650 mg/kg
SEX/DURATION            : female 8-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 24,391,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 24,391,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 gm/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 24,391,1982

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***