*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LU3453000
CHEMICAL NAME           : 2(5H)-Furanone
CAS REGISTRY NUMBER     : 497-23-4
BEILSTEIN REFERENCE NO. : 0383585
REFERENCE               : 5-17-09-00112 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C4-H4-O2
MOLECULAR WEIGHT        : 84.08
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-Butenoic acid, 4-hydroxy-, gamma-lactone
   * 2-Butenoic acid gamma-lactone
   * delta,alpha,beta-Butenolide
   * 2-Buten-4-olide
   * gamma-Crotolactone
   * alpha,beta-Crotonolactone
   * Crotonic acid, 4-hydroxy-, gamma-lactone
   * gamma-Crotonolactone
   * 4-Hydroxy-2-butenoic acid lactone
   * 4-Hydroxy-2-butenoic acid gamma-lactone
   * gamma-Hydroxycrotonic acid lactone
   * Isocrotonolactone
   * 2-Oxo-2,5-dihydrofuran
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 2 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   ACENA7 Acta Endocrinologica (Copenhagen).  (Periodica, Skolegade 12 E,
   DK-2500 Valby, Denmark) V.1-    1948-  Volume(issue)/page/year: 123,571,1990
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 2 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Endocrine - changes in luteinizing hormone
REFERENCE :
   ACENA7 Acta Endocrinologica (Copenhagen).  (Periodica, Skolegade 12 E,
   DK-2500 Valby, Denmark) V.1-    1948-  Volume(issue)/page/year: 123,571,1990

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay

 
                            *** END OF RECORD ***