*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LU3483000
CHEMICAL NAME           : 2(3H)-Furanone,
                          3-(5-(((2-chloroethyl)methylamine)methyl)vanillyl)dih
                          ydro-4-veratryl-, hydrochloride
CAS REGISTRY NUMBER     : 26788-57-8
LAST UPDATED            : 199703
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C25-H32-Cl-N-O6.Cl-H
MOLECULAR WEIGHT        : 514.49
WISWESSER LINE NOTATION : T5OVTJ C1R DQ CO1 E1N1&2G& D1R CO1 DO1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AgM
   * Arctigenin mustard
   * Chloroethylmethylaminomethyl-arctigenin
   *   3-(5-(((2-Chloroethyl)methylamino)methyl)vanillyl)dihydro-4-veratryl-2(3
     H)-furanone HCl
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 236 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Behavioral - analgesia
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 15(4),250,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg/10D-I
TOXIC EFFECTS :
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 15,250,1970
 
                            *** END OF RECORD ***