*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : LU5100000 CHEMICAL NAME : 2(5H)-Furanone, 5-methyl- CAS REGISTRY NUMBER : 591-11-7 BEILSTEIN REFERENCE NO. : 0108058 REFERENCE : 5-17-09-00121 (Beilstein Handbook Reference) LAST UPDATED : 199709 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C5-H6-O2 MOLECULAR WEIGHT : 98.11 COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * alpha,beta-Angelica lactone * beta-Angelica lactone * delta(sup 1)-Angelica lactone * 4-Hydroxy-2-pentenoic acid gamma-lactone * gamma-Methyl-alpha,beta-crotonolactone * 5-Methyl-2(5H)-furanone * 2-Pentanoic acid, 4-hydroxy-, gamma-lactone *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Cardiac - other changes Vascular - regional or general arteriolar or venous dilation Gastrointestinal - ulceration or bleeding from stomach REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 36,355,1929 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2600 mg/kg/65W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 19,392,1965 *** END OF RECORD ***