*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LU5100000
CHEMICAL NAME           : 2(5H)-Furanone, 5-methyl-
CAS REGISTRY NUMBER     : 591-11-7
BEILSTEIN REFERENCE NO. : 0108058
REFERENCE               : 5-17-09-00121 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C5-H6-O2
MOLECULAR WEIGHT        : 98.11
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * alpha,beta-Angelica lactone
   * beta-Angelica lactone
   * delta(sup 1)-Angelica lactone
   * 4-Hydroxy-2-pentenoic acid gamma-lactone
   * gamma-Methyl-alpha,beta-crotonolactone
   * 5-Methyl-2(5H)-furanone
   * 2-Pentanoic acid, 4-hydroxy-, gamma-lactone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   2,109,1946
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Vascular - regional or general arteriolar or venous dilation
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 36,355,1929
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2600 mg/kg/65W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   19,392,1965
 
                            *** END OF RECORD ***