*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LU5800000
CHEMICAL NAME           : 2-Furanpropionic acid,
                          tetrahydro-alpha-(1-naphthylmethyl)-,
                          2-(diethylamino)ethyl ester
CAS REGISTRY NUMBER     : 31329-57-4
BEILSTEIN REFERENCE NO. : 1296059
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C24-H33-N-O3
MOLECULAR WEIGHT        : 383.58
WISWESSER LINE NOTATION : L66J B1YVO2N2&2&1- BT5OTJ
SYNONYMS/TRADE NAMES :
   * N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate
   * 2-(Diethylamino)ethyl  
   tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate
   * Dubimax
   * Nafronyl
   * Naftidrofuryl
   * 3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl  
   ester
   * alpha-Tetrahydrofurfuryl-1-naphthalenepropionic acid  
   2-(diethylamino)ethyl ester
   * Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid  
   2-(diethylamino)ethyl ester
   * Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid  
   2-(diethylamino)ethyl ester
   * Tridus
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1890 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 5,1,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 5,1,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 5,1,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 365 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 10,291,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 129 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 5,1,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 272 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 5,1,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJTXAZ European Journal of Toxicology and Environmental Hygiene.  (Paris,
   France)  V.7-9, 1974-76. For publisher information, see TOERD9.
   Volume(issue)/page/year: 8,188,1975
 
                            *** END OF RECORD ***