*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LV1030000
CHEMICAL NAME           : 5H-Furo(3,2-g)(1)benzopyran-5-one,
                          9-(2-(diethylamino)ethoxy)-4- hydroxy-7-methyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 40709-23-7
LAST UPDATED            : 199806
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H21-N-O5.Cl-H
MOLECULAR WEIGHT        : 367.86
WISWESSER LINE NOTATION : T C566 DO JV MOJ BO2N2&2 HQ L1 &GH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Amikhellin hydrochloride
   * Chlorhydrate d'amikhelline
   * Nokhel
   * 2-Methyl-5-hydroxy-8-(beta-diaethylamino-aethoxy)furano-6,7:2'3'-chromon  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14380 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 13,140,1963
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 110 umol/L
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 55,1415,1973
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 55,1415,1973
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 270 umol/L/6H (Continuous)
REFERENCE :
   AAMMAU Archives d'Anatomie Microscopique et de Morphologie Experimentale.
   (SPPIF, B.P.22, F-41353 Vineuil, France) V.36-76, 1947-1987.  For publisher
   information,  see BSTME2.  Volume(issue)/page/year: 61,201,1972
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 55,1415,1973
 
                            *** END OF RECORD ***