*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : LV2476200
CHEMICAL NAME           : Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one,
                          5,8,8a,9-tetrahydro-9-hydroxy-5-(4-
                          hydroxy-3,5-dimethoxyphenyl)-,
                          (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-
CAS REGISTRY NUMBER     : 6559-91-7
BEILSTEIN REFERENCE NO. : 1358259
REFERENCE               : 5-19-10-00665 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H20-O8
MOLECULAR WEIGHT        : 400.41
WISWESSER LINE NOTATION : T E5 C665 FVO NO PO OHTT&&J DR DQ CO1 EO1& JQ
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 4'-Demethylepipodophyllotoxin
 
                       *** HEALTH HAZARD DATA ***
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   JNPRDF Journal of Natural Products.  (Spahr & Glenn Co., 225 E. Spring St.,
   Columbus, OH 43215) V.42-    1979-  Volume(issue)/page/year: 52,606,1989
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 100 umol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 15,5443,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 2 umol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 15,5443,1976
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 umol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 15,5443,1976

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation

 
                            *** END OF RECORD ***